Article

Silencing of an efflux pump coding gene decreases the efflux rate of pyrazinoic acid in <i>Mycobacterium smegmatis</i>

2021-10-30

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (MTB). The recommended treatment for TB is based on the use of first-line drugs, including pyrazinamide (PZA). PZA is also a drug used in the treatment of multidrug-resistant TB (MDR-TB) because of its main effect against the latent stage. The main cause of resistance to PZA is mutations in the...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 81513ff5-d870-5dff-81a4-31d879ed7a6b
DOI: 10.1101/2021.10.29.466536

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Silencing of an efflux pump coding gene decreases the efflux rate of pyrazinoic acid in <i>Mycobacterium smegmatis</i>DOI 10.1101/2021.10.29.466536Read

Mutations in <i>panD</i> encoding aspartate decarboxylase are associated with pyrazinamide resistance in <i>Mycobacterium tuberculosis</i>Semantic proximity Read

Deciphering the transcriptomic landscape of pyrazinamide resistance in <i>Mycobacterium tuberculosis</i>Semantic proximity Read

Pyrazinamide resistance in Mycobacterium tuberculosis: Review and update.Semantic proximity Read

Mycobacterium smegmatis msmeg_3314 is involved in pyrazinamide and fluoroquinolones susceptibility via NAD+/NADH dysregulation.Semantic proximity Read

Metabolic control of drug resistance by a mycobacterial ion channelSemantic proximity Read

Effects of CwlM, a peptidoglycan synthesis regulator, on beta-lactam resistance and host-pathogen interactionsSemantic proximity Read

Efflux as a mechanism for drug resistance in<i>Mycobacterium tuberculosis</i>: Table 1Semantic proximity Read

Pyrazinamide Resistance Is Caused by Two Distinct Mechanisms: Prevention of Coenzyme A Depletion and Loss of Virulence Factor SynthesisSemantic proximity Read

Pyrazinamide Susceptibility Is Driven by Activation of the SigE-Dependent Cell Envelope Stress Response in Mycobacterium tuberculosis.Semantic proximity Read

A Recombinase Polymerase Amplification-Coupled Cas12a Mutant-Based Module for Efficient Detection of Streptomycin-Resistant Mutations in Mycobacterium tuberculosisSemantic proximity Read

The Phosphate-Specific Transport System Gene <i>pstA1</i> Contributes to Rifampin Tolerance in <i>Mycobacterium tuberculosis</i>Semantic proximity Read

Reprogramming Mycobacterium Tuberculosis CRISPR System for Gene Editing and Genome-Wide RNA Interference ScreeningSemantic proximity Read