Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pyrazinamide Susceptibility Is Driven by Activation of the SigE-Dependent Cell Envelope Stress Response in Mycobacterium tuberculosis.

mBio - 22 Feb 2021

Thiede Joshua M, Dillon Nicholas A, Howe Michael D, Aflakpui Ranee, Modlin Samuel J, Hoffner Sven E, Valafar Faramarz, Minato Yusuke, Baughn Anthony D

Abstract excerpt

Pyrazinamide (PZA) plays a crucial role in first-line tuberculosis drug therapy. Unlike other antimicrobial agents, PZA is active against Mycobacterium tuberculosis only at low pH. The basis for this conditional drug susceptibility remains undefined. In this study, we utilized a genome-wide approach to interrogate potentiation of PZA action. We found that mutations in numerous genes involved in central metabolism...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amidohydrolases
Share to Antitubercular Agents

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Microbial Sensitivity Tests

Share to Mutation

Share to Mycobacterium tuberculosis

Share to Pyrazinamide

Share to Tuberculosis

Share to Tuberculosis Research and Epidemiology

Source

Open in PubMed Open full text

Identifiers

PMID: 35100871
DOI: 10.1128/mbio.00439-21
PMCID: PMC8805019

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pyrazinamide Susceptibility Is Driven by Activation of the SigE-Dependent Cell Envelope Stress Response in Mycobacterium tuberculosis.PMID 35100871Read ↗

Deciphering the transcriptomic landscape of pyrazinamide resistance in <i>Mycobacterium tuberculosis</i>Semantic proximity Read ↗

Comparative transcriptomic profiling of pyrazinamide resistance in Mycobacterium tuberculosis.Semantic proximity Read ↗

A multiple genome analysis of Mycobacterium tuberculosis reveals specific novel genes and mutations associated with pyrazinamide resistance.Semantic proximity Read ↗

Pyrazinamide resistance in Mycobacterium tuberculosis: Review and update.Semantic proximity Read ↗

Silencing of an efflux pump coding gene decreases the efflux rate of pyrazinoic acid in <i>Mycobacterium smegmatis</i>Semantic proximity Read ↗

The Bewildering Antitubercular Action of Pyrazinamide.Semantic proximity Read ↗

Mutations Associated with Pyrazinamide Resistance in Mycobacterium tuberculosis: A Review and Update.Semantic proximity Read ↗

Metabolic control of drug resistance by a mycobacterial ion channelSemantic proximity Read ↗

The stress response factor SigH mediates intrinsic resistance to multiple antibiotics in <i>Mycobacterium abscessus</i>Semantic proximity Read ↗

Pyrazinamide triggers degradation of its target aspartate decarboxylase.Semantic proximity Read ↗

Emerging insight of whole genome sequencing coupled with protein structure prediction into the pyrazinamide-resistance signature of Mycobacterium tuberculosis.Semantic proximity Read ↗

Pyrazinamide Resistance Is Caused by Two Distinct Mechanisms: Prevention of Coenzyme A Depletion and Loss of Virulence Factor SynthesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.