Back to search

Article

IPSC-derived midbrain astrocytes from Parkinson’s disease patients carrying pathogenic <i>SNCA</i> mutations exhibit alpha-synuclein aggregation, mitochondrial fragmentation and excess calcium release

2020-04-28

Abstract excerpt

Parkinson’s disease (PD) is characterized by the loss of A9 midbrain dopaminergic neurons and the accumulation of alpha-synuclein aggregates in remaining neurons. Many studies of the molecular and cellular basis of neurodegeneration in PD have made use of iPSC-derived neurons from patients with familial PD mutations. However, approximately half of the cells in the brain are glia, and their role facilitating neurod...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
6fbfb685-44f0-5169-9f51-2643503c03bb
DOI
10.1101/2020.04.27.053470
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
IPSC-derived midbrain astrocytes from Parkinson’s disease patients carrying pathogenic <i>SNCA</i> mutations exhibit alpha-synuclein aggregation, mitochondrial fragmentation and excess calcium releaseDOI 10.1101/2020.04.27.053470
Dysregulated proteostasis in p.A53T-α-Synuclein astrocytes aggravates Lewy-like neuropathology in a Parkinson's disease iPSC model.Semantic proximity
Proteostasis dysregulation in p.A53T-α-Synuclein iPSC-derived astrocytes exacerbates neurodegeneration in a Parkinson’s disease model with Lewy-like pathologySemantic proximity
Patient-Specific iPSC-Derived Astrocytes Contribute to Non-Cell-Autonomous Neurodegeneration in Parkinson's DiseaseSemantic proximity
Mitochondrial Metabolism and Calcium Handling in Parkinson's Disease hiPSC-derived AstrocytesSemantic proximity
PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer's DiseaseSemantic proximity
Synaptic decline precedes dopaminergic neuronal loss in human midbrain organoids harboring a triplication of the <i>SNCA</i> geneSemantic proximity
Protein aggregation and calcium dysregulation are the earliest hallmarks of synucleinopathy in human midbrain dopaminergic neuronsSemantic proximity
Mitochondrial Dysfunction in Astrocytes: A Role in Parkinson’s Disease?Semantic proximity
Astrocytic atrophy as a pathological feature of Parkinson’s disease with LRRK2 mutationSemantic proximity
Metabolic alterations in Parkinson's disease astrocytes.Semantic proximity
Autophagy Dysfunction in iPSCs-Derived Neurons and Midbrain Organoids Carrying a <i>SNCA</i> TriplicationSemantic proximity
Modeling Cell-Cell Interactions in Parkinson’s Disease Using Human Stem Cell-Based ModelsSemantic proximity
Select a neighboring publication to make it the new centre.