Article

Optimization of AAV tools to target Muller glial cells for retinal gene therapy

2025-12-16

Abstract excerpt

Reprogramming of Muller glial (MG) cells into retinal neurons has the potential to treat vision loss by regenerating the retina. Development of efficient gene delivery systems to target the MG cells is critical. Adeno-associated virus (AAV) serotypes and promoter specificity are important factors that influence AAV transduction profile in the retina. However, studies that optimize these parameters to specifically...

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Literature Corpus work: 77517aac-c5df-5f76-91f0-771c5a80e0cd
DOI: 10.64898/2025.12.15.694492

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