Article

A somatic evolutionary model of the dynamics of aneuploid cells during hematopoietic reconstitution

2018-06-26

Abstract excerpt

Aneuploidy is associated with many cancers. Recent studies demonstrate that in thehematopoietic stem and progenitor cell (HSPC) compartment aneuploid cells havereduced fitness and are efficiently purged from the bone marrow. However, early phasesof hematopoietic reconstitution following bone marrow transplantation provide awindow of opportunity whereby aneuploid cells rise in frequency, only to decline to basallev...

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Literature Corpus work: 81090b09-e853-5940-9a5b-3f15b52c7522
DOI: 10.1101/355826

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