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Article

Evolutionary rescue by aneuploidy in tumors exposed to anticancer drugs.

Genetics - 9 Jul 2025

Stana Remus, Ben-David Uri, Weissman Daniel B, Ram Yoav

Abstract excerpt

Evolutionary rescue occurs when a population, facing a sudden environmental change that would otherwise lead to extinction, adapts through beneficial mutations, allowing it to recover and persist. A prime example of evolutionary rescue is the ability of cancer to survive exposure to treatment. One evolutionary mechanism by which a population of cancer cells can adapt to chemotherapy is aneuploidy. Aneuploid...

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Identifiers

PMID: 40404288
DOI: 10.1093/genetics/iyaf098
PMCID: PMC12239212

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