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Circadian Disruption Exacerbates Innate Immune Responses by Modulating the Bistability of Pro-Inflammatory Signaling: A dynamical Modeling Study

2026-06-02

Abstract excerpt

Circadian disruption resulting from factors such as jet lag, shift work, or aging leads to exaggerated inflammatory responses and increased disease susceptibility. However, the core dynamical mechanism by which circadian disruption exacerbates innate immune responses remains poorly understood. Here, we develop an integrated mathematical model coupling the mammalian circadian clock with antigen-induced innate immun...

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Literature Corpus work
2a154a07-a945-5667-bcfc-0c6d90f56f49
DOI
10.20944/preprints202606.0096.v1
Open publication

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Circadian Disruption Exacerbates Innate Immune Responses by Modulating the Bistability of Pro-Inflammatory Signaling: A dynamical Modeling StudyDOI 10.20944/preprints202606.0096.v1
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