Article

Why Static Biomarkers Often Fall Short: Circadian Immune Coherence as a Missing Dimension in Immunotherapy

2026-01-21

Abstract excerpt

Despite major advances in cancer immunotherapy, clinical decision-making still relies heavily on static biomarkers derived from single time-point measurements, such as PD-L1 expression or baseline inflammatory indices. While these markers provide partial prognostic and predictive information, they often fail to capture the dynamic and time-dependent nature of host–tumor immune interactions. Growing evidence from c...

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Literature Corpus work: 78b73500-f2af-55f7-9057-c447dbc88e29
DOI: 10.12688/f1000research.176828.1

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