Article

Why Static Biomarkers Often Fall Short: Circadian Immune Coherence as a Missing Dimension in Immunotherapy

2026-07-15

Abstract excerpt

Despite major advances in cancer immunotherapy, clinical decision-making still relies heavily on static biomarkers derived from single time-point measurements, such as PD-L1 expression or baseline inflammatory indices. While informative, these markers fail to capture the dynamic and time-dependent nature of host–tumor immune interactions. Accumulating evidence from circadian biology shows that immune cell traffick...

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Literature Corpus work: 64105053-fb19-5766-8272-80b08a86e9b0
DOI: 10.12688/f1000research.176828.2

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