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Article

Use of Transgenic Mice in Carcinogenicity Hazard Assessment

1 Jan 2004

Abstract excerpt

Determining the carcinogenic potential of materials to which humans have significant exposure is an important, complex and imperfect exercise. Not only are the methods for such determinations protracted, expensive and utilize large numbers of animals, extrapolation of data from such studies to human risk is imprecise. Toxicologists have long recognized these shortcomings but the 2-year chronic rodent study has...

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PMID: 15209403
DOI: 10.1080/01926230490424761

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