Article
Guidelines on severity assessment and classification of genetically altered mouse and rat lines.
Laboratory animals - 1 Dec 2017
Zintzsch Anne, Noe Elena, Reißmann Monika, Ullmann Kristina, Krämer Stephanie, Jerchow Boris, Kluge Reinhart, Gösele Claudia, Nickles Hannah, Puppe Astrid, Rülicke Thomas
Abstract excerpt
Genetic alterations can unpredictably compromise the wellbeing of animals. Thus, more or less harmful phenotypes might appear in the animals used in research projects even when they are not subjected to experimental treatments. The severity classification of suffering has become an important issue since the implementation of Directive 2010/63/EU on the protection of animals used for scientific purposes....
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