Using Mice to Model Human Disease: Understanding the Roles of Baseline Housing-Induced and Experimentally Imposed Stresses in Animal Welfare and Experimental Reproducibility

Abstract excerpt

Mice are the most common animal used to study disease, but there are real concerns about the reproducibility of many of these experiments. This review discusses how several different sources of chronic stress can directly impact experimental outcomes. Mandated housing conditions induce an underappreciated level of chronic stress but are not usually considered or reported as part of the experimental design. Since...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cancer, Stress, Anesthesia, and Immune Response
• Share to Stress Responses and Cortisol