Article

Disordered breathing in a mouse model of Dravet syndrome

2018-11-14

Abstract excerpt

<h4>ABSTRACT</h4> Dravet syndrome (DS) is a form of epilepsy with a high incidence of sudden unexpected death in epilepsy (SUDEP). Respiratory failure is a leading cause of SUDEP, and DS patients’ frequently exhibit disordered breathing. Despite this, mechanisms underlying respiratory dysfunction in DS are entirely unknown. We found that mice expressing a recurrent SCN1a missense mutation (A1783V) conditionally...

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Literature Corpus work: 783462c0-779b-54b8-8008-0676545c765f
DOI: 10.1101/470609

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