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Transcriptome analysis reveals molecularly distinct subtypes in retinoblastoma

30 Sept 2023

Abstract excerpt

Retinoblastoma is the most frequent intraocular malignancy in children. Little is known on the molecular basis underlying the biological and clinical behavior of this cancer. Here, using gene expression profiles, we demonstrate the existence of two major retinoblastoma subtypes that can be divided into six subgroups. Subtype 1 has higher expression of cone related genes and higher percentage of RB1 germline...

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PMID: 37777551
DOI: 10.1038/s41598-023-42253-4

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