Article
Etiology including epigenetic defects of retinoblastoma.
Asia-Pacific journal of ophthalmology (Philadelphia, Pa.) - 1 Jan 2000
Zhou Linbin, Tong Yan, Ho Bo Man, Li Jiahui, Chan Hoi Ying Emily, Zhang Tian, Du Lin, He Jing Na, Chen Li Jia, Tham Clement C, Yam Jason C, Pang Chi Pui, Chu Wai Kit
Abstract excerpt
Retinoblastoma (RB), originating from the developing retina, is an aggressive intraocular malignant neoplasm in childhood. Biallelic loss of RB1 is conventionally considered a prerequisite for initiating RB development in most RB cases. Additional genetic mutations arising from genome instability following RB1 mutations are proposed to be required to promote RB development. Recent advancements in high throughput...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.