Article
E2F1/CKS2/PTEN signaling axis regulates malignant phenotypes in pediatric retinoblastoma.
Cell death & disease - 12 Sept 2022
Chen Meng, Zhao Zhaozhao, Wu Lianqun, Huang Jiancheng, Yu Peng, Qian Jiang, Ni Ting, Zhao Chen
Abstract excerpt
Retinoblastoma (RB) is the most common pediatric intraocular malignancy and is a serious vision- and life-threatening disease. The biallelic mutation of the retinoblastoma gene RB1 is the initial event in the malignant transformation of RB, but the exact molecular mechanism is still unclear. E2F transcription factors can be activated by RB1 loss of function and lead to uncontrolled cell division. Among E2F family...
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