Article
Single-cell characterization of malignant phenotypes and microenvironment alteration in retinoblastoma.
Cell death & disease - 6 May 2022
Wu Cheng, Yang Jiaqi, Xiao Wei, Jiang Zehang, Chen Shuxia, Guo Dianlei, Zhang Ping, Liu Chunqiao, Yang Huasheng, Xie Zhi
Abstract excerpt
Retinoblastoma (RB) is the most common primary intraocular malignancy of childhood. It is known that the tumor microenvironment (TME) regulates tumorigenesis and metastasis. However, how the malignant progression in RB is determined by the heterogeneity of tumor cells and TME remains uncharacterized. Here, we conducted integrative single-cell transcriptome and whole-exome sequencing analysis of RB patients with...
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