Article

Local and circulating cytotoxic CD4⁺ T cells are early markers of disease activity in pediatric Crohn’s disease

2026-06-26

Abstract excerpt

Inflammatory bowel disease (IBD) burden is rising globally, yet only subsets of patients benefit from available therapies, underscoring the need for more precise molecular and cellular stratification. In the PREDICT study, we enrolled treatment-naïve pediatric patients with IBD, alongside disorders of gut–brain interaction (DGBI) controls and healthy donors, and profiled their intestinal and blood-derived T cells...

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Literature Corpus work: 0752c154-ca2e-5d58-b987-d059e3bbaf09
DOI: 10.64898/2026.06.16.26354238

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