Article

Guardian crypt-base-goblet-cells protect the human colonic stem cell niche by triggering cholinergic calcium signal-dependent MUC2 secretion and luminal flushing

2022-01-04

Abstract excerpt

<h4>ABSTRACT</h4> Mucus secreting goblet cells play a vital role in the maintenance of tissue homeostasis. Here we report the discovery of an enigmatic mechanism for the generation of calcium signals that couple cholinergic input to secretion of hydrated mucus in the human colonic stem cell niche. Mechanistic insights for this study were derived from native human colonic crypts and crypt-like organoids expressing...

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Literature Corpus work: 80c523c6-460b-5ff0-a78e-4022225ac88b
DOI: 10.1101/2022.01.04.474646

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