Article

Genomic loss of GPR108 disrupts AAV transduction in birds

2024-05-17

Abstract excerpt

The G protein-coupled receptor 108 ( GPR108 ) gene encodes a protein factor identified as critical for adeno-associated virus (AAV) entry into mammalian cells, but whether it is universally involved in AAV transduction is unknown. Remarkably, we have discovered that GPR108 is absent in the genomes of birds and in most other sauropsids, providing a likely explanation for the overall lower AAV transduction efficac...

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Literature Corpus work: 80be8b3f-f738-5a26-a642-68406771a7a8
DOI: 10.1101/2024.05.16.589954

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