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Article

GPR108 Is a Highly Conserved AAV Entry Factor

12 Nov 2019

Abstract excerpt

Adeno-associated virus (AAV) is a highly promising gene transfer vector, yet major cellular requirements for AAV entry are poorly understood. Using a genome-wide CRISPR screen for entry of evolutionarily divergent serotype AAVrh32.33, we identified GPR108, a member of the G protein-coupled receptor superfamily, as an AAV entry factor. Of greater than 20 divergent AAVs across all AAV clades tested in human cell...

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PMID: 31784416
DOI: 10.1016/j.ymthe.2019.11.005

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