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Article

Identification of host essential factors for recombinant AAV transduction of the polarized human airway epithelium

15 Nov 2023

Abstract excerpt

ABSTRACT Recombinant (r)AAV2.5T was selected from the directed evolution of an adeno-associated virus (AAV) capsid library in the human airway epithelium (HAE). The capsid gene of rAAV2.5T is a chimera of the N-terminal unique coding sequence of AAV2 VP1 unique (VP1u) and the VP2- and VP3-coding sequences of AAV5 with a single amino acid mutation of A581T. We conducted two rounds of genome-wide CRISPR guide...

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Identifiers

PMID: 37966249
DOI: 10.1128/jvi.01330-23

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