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Article

Targeted gene delivery to the enteric nervous system using AAV: a comparison across serotypes and capsid mutants.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 Mar 2015

Benskey Matthew J, Kuhn Nathan C, Galligan James J, Garcia Joanna, Boye Shannon E, Hauswirth William W, Mueller Christian, Boye Sanford L, Manfredsson Fredric P

Abstract excerpt

Recombinant adeno-associated virus (AAV) vectors are one of the most widely used gene transfer systems in research and clinical trials. AAV can transduce a wide range of biological tissues, however to date, there has been no investigation on targeted AAV transduction of the enteric nervous system (ENS). Here, we examined the efficiency, tropism, spread, and immunogenicity of AAV transduction in the ENS. Rats...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25592336
DOI: 10.1038/mt.2015.7
PMCID: PMC4351472

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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