Article
Microneedle array design determines the induction of protective memory CD8+ T cell responses induced by a recombinant live malaria vaccine in mice.
PloS one - 1 Jan 2011
Carey John B, Pearson Frances E, Vrdoljak Anto, McGrath Marie G, Crean Abina M, Walsh Patrick T, Doody Timothy, O'Mahony Conor, Hill Adrian V S, Moore Anne C
Abstract excerpt
BACKGROUND: Vaccine delivery into the skin has received renewed interest due to ease of access to the immune system and microvasculature, however the stratum corneum (SC), must be breached for successful vaccination. This has been achieved by removing the SC by abrasion or scarification or by delivering the vaccine intradermally (ID) with traditional needle-and-syringes or with long microneedle devices....
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