Article

Structural Basis for Antibody Neutralization of Pertussis Toxin

2024-09-23

Abstract excerpt

<h4>SUMMARY/ABSTRACT</h4> Pertussis toxin (PT) is a key protective antigen in vaccine- and natural immunity-mediated protection from Bordetella pertussis infection. Despite its importance, no PT-neutralizing epitopes have been characterized structurally. To define neutralizing epitopes and identify key structural elements to preserve during PT antigen design, we determined a 3.6 Å cryo-electron microscopy struct...

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Literature Corpus work: 59b9a2b2-dce2-5a54-b4eb-eab642b4b901
DOI: 10.1101/2024.09.23.614357

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