Immunotoxins with decreased immunogenicity and improved activity.

doi:10.3109/10428194.2011.573039

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Article

Immunotoxins with decreased immunogenicity and improved activity.

Leukemia & lymphoma - 1 Jun 2011

Pastan Ira, Onda Masanori, Weldon John, Fitzgerald David, Kreitman Robert

Abstract excerpt

Recombinant immunotoxins, containing an Fv fragment and a bacterial toxin, frequently elicit neutralizing antibodies, nearly always against the toxin. Moxetumomab pasudotox (previously called CAT-8015 or HA22) contains an anti-CD22 Fv fused to PE38, a truncated form of Pseudomonas exotoxin, containing amino acids 253-364 and 381-613. One avenue to reducing immunogenicity is to identify B- and T-cell epitopes and...

Topics

Animals
Epitopes, B-Lymphocyte
Humans
Immunotoxins
Leukemia, Lymphocytic, Chronic, B-Cell
Mice
Mutation

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PMID: 21504287
DOI: 10.3109/10428194.2011.573039
PMCID: PMC7435130

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