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Associations Between Ambient Air Pollution and Cognitive Abilities from Midlife to Early Old Age: Modification by APOE Genotype.

Journal of Alzheimer's disease : JAD - 1 Jan 2023

Franz Carol E, Gustavson Daniel E, Elman Jeremy A, Fennema-Notestine Christine, Hagler Donald J, Baraff Aaron, Tu Xin M, Wu Tsung-Chin, De Anda Jaden, Beck Asad, Kaufman Joel D, Whitsel Nathan, Finch Caleb E, Chen Jiu-Chiuan, Lyons Michael J, Kremen William S

Abstract excerpt

BACKGROUND: Fine particulate matter (PM2.5) and nitrogen dioxide (NO2) measures of ambient air pollution are associated with accelerated age-related cognitive impairment, and Alzheimer's disease and related dementias (ADRD). OBJECTIVE: We examined associations between air pollution, four cognitive factors, and the moderating role of apolipoprotein E (APOE) genotype in the understudied period of midlife. METHODS:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36970897
DOI: 10.3233/JAD-221054
PMCID: PMC10827529

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