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The Egyptian Rousette Genome Reveals Unexpected Features of Bat Antiviral Immunity.

Cell - 17 May 2018

Pavlovich Stephanie S, Lovett Sean P, Koroleva Galina, Guito Jonathan C, Arnold Catherine E, Nagle Elyse R, Kulcsar Kirsten, Lee Albert, Thibaud-Nissen Françoise, Hume Adam J, Mühlberger Elke, Uebelhoer Luke S, Towner Jonathan S, Rabadan Raul, Sanchez-Lockhart Mariano, Kepler Thomas B, Palacios Gustavo

Abstract excerpt

Bats harbor many viruses asymptomatically, including several notorious for causing extreme virulence in humans. To identify differences between antiviral mechanisms in humans and bats, we sequenced, assembled, and analyzed the genome of Rousettus aegyptiacus, a natural reservoir of Marburg virus and the only known reservoir for any filovirus. We found an expanded and diversified KLRC/KLRD family of natural killer...

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Identifiers

PMID: 29706541
DOI: 10.1016/j.cell.2018.03.070
PMCID: PMC7112298

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