Article

Extensive adaptive changes in bat interferon pathway reveal specific molecular functions at the forefront of host–virus coevolution

2025-09-19

Abstract excerpt

The interferon (IFN) response is a fundamental component of the mammalian innate immune system, orchestrating a broad antiviral state through a network of interferon-stimulated genes (ISGs). In bats, which are natural reservoirs for diverse viruses, several ISGs exhibit lineage-specific evolutionary adaptations, reflecting unique immune strategies. While previous research has typically focused on individual ISGs o...

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Literature Corpus work: 0e81cfd4-7e87-5737-8660-195adab45a00
DOI: 10.1101/2025.09.17.676773

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