Article

Cryo-electron tomography reveals the microtubule-bound form of inactive LRRK2

2024-06-20

Abstract excerpt

Parkinson’s Disease (PD) is the second most common neurodegenerative disorder. Mutations in leucine-rich repeat kinase 2 (LRRK2), a multi-domain protein containing both a kinase and a GTPase, are a leading cause of the familial form of PD. Pathogenic LRRK2 mutations increase LRRK2 kinase activity. While the bulk of LRRK2 is found in the cytosol, the protein associates with membranes where its Rab GTPase substrates...

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Literature Corpus work: 801fc84a-eab9-5a47-b6a4-85ce760da712
DOI: 10.1101/2024.06.18.599606

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