Article

Identification of a Musashi2 translocation as a novel oncogene in myeloid leukemia

2023-12-29

Abstract excerpt

Myeloid leukemias, diseases marked by aggressiveness and poor outcomes, are frequently triggered by oncogenic translocations. In the case of chronic myelogenous leukemia (CML) the BCR-ABL fusion initiates chronic phase disease with second hits allowing progression to blast crisis. Although Gleevec has been transformative for CML, blast crisis CML remains relatively drug resistant. Here we show that MSI2-HOXA9, a t...

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Literature Corpus work: 801f9257-8d59-5c48-af11-2f355a493339
DOI: 10.1101/2023.12.29.573601

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