Article

Multiplex, multimodal mapping of variant effects in secreted proteins

2024-04-01

Abstract excerpt

Despite widespread advances in DNA sequencing, the functional consequences of most genetic variants remain poorly understood. Multiplexed Assays of Variant Effect (MAVEs) can measure the function of variants at scale, and are beginning to address this problem. However, MAVEs cannot readily be applied to the ∼10% of human genes encoding secreted proteins. We developed a flexible, scalable human cell surface display...

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Literature Corpus work: 8012c51e-45e6-5740-9ca0-9de989dd65a0
DOI: 10.1101/2024.04.01.587474

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