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High-throughput identification of autoantibodies that target the human exoproteome

1 Feb 2022

Abstract excerpt

Autoantibodies that recognize extracellular proteins (the exoproteome) exert potent biological effects but are challenging to detect. Here, we developed rapid extracellular antigen profiling (REAP), a high-throughput technique for the comprehensive discovery of exoproteome-targeting autoantibodies. Patient samples are applied to a genetically barcoded yeast surface display library containing 2,688 human...

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PMID: 35360706
DOI: 10.1016/j.crmeth.2022.100172

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