Article

Phenotypic pleiotropy of missense variants in human B cell-confinement receptor P2RY8

2025-03-06

Abstract excerpt

Missense variants can have pleiotropic effects on protein function and predicting these effects can be difficult. We performed near-saturation deep mutational scanning of P2RY8, a G-protein-coupled receptor that promotes germinal center B cell confinement. We assayed the effect of each variant on surface expression, migration, and proliferation. We delineated variants that affected both expression and function, af...

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Literature Corpus work: 543b0bd0-071d-5a88-aec6-897157c0441c
DOI: 10.1101/2025.02.28.640567

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