Article
Statistical methods for testing X chromosome variant associations: application to sex-specific characteristics of bipolar disorder.
Biology of sex differences - 9 Dec 2019
Jons William A, Colby Colin L, McElroy Susan L, Frye Mark A, Biernacka Joanna M, Winham Stacey J
Abstract excerpt
BACKGROUND: Bipolar disorder (BD) affects both sexes, but important sex differences exist with respect to its symptoms and comorbidities. For example, rapid cycling (RC) is more prevalent in females, and alcohol use disorder (AUD) is more prevalent in males. We hypothesize that X chromosome variants may be associated with sex-specific characteristics of BD. Few studies have explored the role of the X chromosome...
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