Article

Gut microbiota-derived butyrate orchestrates Astragalus Polysaccharide-mediated colitis remission via macrophage immunometabolic reprogramming

2026-02-06

Abstract excerpt

<title>Abstract</title> <p> Ulcerative colitis (UC) pathogenesis involves complex interactions between epithelial barrier dysfunction and immune dysregulation. While Astragalus polysaccharide (APS) exhibits anti-inflammatory properties, its mechanistic link to gut microbiota remodeling remains elusive. Using an integrative multi-omics strategy, we demonstrate that APS mitigates dextran sulfate sodium (DSS)-induc...

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Literature Corpus work: 6a231f5e-7633-5504-8b56-76712b2b8306
DOI: 10.21203/rs.3.rs-8501578/v1

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