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Article

Polygenic risk score-guided personalized osteoporosis screening: a population-based study.

BMC medicine - 14 Jan 2026

Wang Dongxue, Sun Wen, Liu Di, Yi Huan, Wang Xiao, Li Xiaodan, Ji Jianguang

Abstract excerpt

BACKGROUND: Despite robust evidence that genetic factors substantially influence both osteoporosis development and fracture risk, current screening guidelines fail to incorporate genetic factors into risk-assessment protocols. This study aims to determine personalized screening ages for osteoporosis based on polygenic risk score (PRS). METHODS: This prospective cohort study utilized data from 223,818 women in the...

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Identifiers

PMID: 41530839
DOI: 10.1186/s12916-025-04601-1
PMCID: PMC12849559

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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