Article

CaMKKβ regulates transcription factor Elf2 gene methylation to maintain endothelial junctional barrier integrity

2025-02-27

Abstract excerpt

The expression of endothelial-enriched receptor tyrosine kinase Tie2 and vascular endothelial cadherin VE-cadherin in endothelial cells (EC) is essential for maintaining endothelial barrier integrity and vascular homeostasis. The Ets family of transcription factors plays a critical role in regulating the expression of Tie2 and VE-cadherin in EC. However, the transcriptional regulation of these factors remains poor...

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Literature Corpus work: 7faa10d8-5947-5c0d-a98b-ca5076a896c0
DOI: 10.1101/2025.02.27.640631

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