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Article

Histone and DNA methylation-mediated epigenetic downregulation of endothelial Kruppel-like factor 2 by low-density lipoprotein cholesterol.

Arteriosclerosis, thrombosis, and vascular biology - 1 Aug 2013

Kumar Ajay, Kumar Santosh, Vikram Ajit, Hoffman Timothy A, Naqvi Asma, Lewarchik Christopher M, Kim Young-Rae, Irani Kaikobad

Abstract excerpt

OBJECTIVE: Low-density lipoprotein (LDL) cholesterol induces endothelial dysfunction and is a major modifiable risk factor for coronary heart disease. Endothelial Kruppel-like Factor 2 (KLF2) is a transcription factor that is vital to endothelium-dependent vascular homeostasis. The purpose of this study is to determine whether and how LDL affects endothelial KLF2 expression. APPROACH AND RESULTS: LDL...

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Source

Identifiers

PMID: 23723375
DOI: 10.1161/ATVBAHA.113.301765

Genes

KLF2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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