Histone and DNA methylation-mediated epigenetic downregulation of endothelial Kruppel-like factor 2 by low-density lipoprotein cholesterol.

doi:10.1161/ATVBAHA.113.301765

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Back to search

Article

Histone and DNA methylation-mediated epigenetic downregulation of endothelial Kruppel-like factor 2 by low-density lipoprotein cholesterol.

Arteriosclerosis, thrombosis, and vascular biology - 1 Aug 2013

Kumar Ajay, Kumar Santosh, Vikram Ajit, Hoffman Timothy A, Naqvi Asma, Lewarchik Christopher M, Kim Young-Rae, Irani Kaikobad

Abstract excerpt

OBJECTIVE: Low-density lipoprotein (LDL) cholesterol induces endothelial dysfunction and is a major modifiable risk factor for coronary heart disease. Endothelial Kruppel-like Factor 2 (KLF2) is a transcription factor that is vital to endothelium-dependent vascular homeostasis. The purpose of this study is to determine whether and how LDL affects endothelial KLF2 expression. APPROACH AND RESULTS: LDL...

Topics

Atherosclerosis
Cholesterol, LDL
DNA Methylation
Down-Regulation
Endothelial Cells
Enhancer of Zeste Homolog 2 Protein
Epigenesis, Genetic
Histones
Human Umbilical Vein Endothelial Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Kruppel-Like Transcription Factors

MADS Domain Proteins

MEF2 Transcription Factors

Methyl-CpG-Binding Protein 2

Myogenic Regulatory Factors

Phenotype

Polycomb Repressive Complex 2

Promoter Regions, Genetic

Source

Open in PubMed

Identifiers

PMID: 23723375
DOI: 10.1161/ATVBAHA.113.301765

Genes

KLF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Histone and DNA methylation-mediated epigenetic downregulation of endothelial Kruppel-like factor 2 by low-density lipoprotein cholesterol.PMID 23723375Read ↗

Site-specific microRNA-92a regulation of Kruppel-like factors 4 and 2 in atherosusceptible endothelium.Semantic proximity Read ↗

Krüppel-like factors in endothelial cell biologySemantic proximity Read ↗

Histone modification of endothelial-mesenchymal transition in cardiovascular diseasesSemantic proximity Read ↗

Integration of flow-dependent endothelial phenotypes by Kruppel-like factor 2.Semantic proximity Read ↗

Polycomb Repressive Complex 2 promotes atherosclerotic plaque vulnerabilitySemantic proximity Read ↗

Silencing <i>KRIT1</i> Partially Reverses the Effects of Disturbed Flow on the Endothelial Cell TranscriptomeSemantic proximity Read ↗

MicroRNA-Based Therapy of GATA2-Deficient Vascular DiseaseSemantic proximity Read ↗

Pharmacological inhibition of the heart of glass (HEG1)-Krev interaction trapped protein 1 (KRIT1) protein complex increases Krüppel-like Factors 4 and 2 (KLF4/2) expression in endothelial cellsSemantic proximity Read ↗

Role of Krüppel-Like Factor 4 and its Binding Proteins in Vascular DiseaseSemantic proximity Read ↗

MEG8 regulates Tissue Factor Pathway Inhibitor 2 (TFPI2) expression in the endotheliumSemantic proximity Read ↗

Erk5 activation elicits a vasoprotective endothelial phenotype via induction of Kruppel-like factor 4 (KLF4).Semantic proximity Read ↗

The angiopoietin receptor Tie2 is atheroprotective in arterial endotheliumSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.