ISG15 Differentially Modulates Clade Ib and II MPXV Infection

Abstract excerpt

<title>Abstract</title> <p>The unprecedented human-to-human transmission of Clade IIb monkeypox virus (MPXV) during the 2022 outbreak has renewed focus on host determinants of viral fitness. Interferon-stimulated gene 15 (ISG15) encodes a ubiquitin-like protein with broad immunomodulatory functions, yet its role in MPXV infection remains unclear. Using representative strains from recent and historical outbreaks s...

Topics

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• Cytokine Signaling Pathways and Interactions
• Herpesvirus Infections and Treatments
• interferon and immune responses
• Poxvirus research and outbreaks
• RNA regulation and disease
• Vector-Borne Animal Diseases
• Viral Infections and Vectors
• Virus-based gene therapy research

Identifiers and source

Literature Corpus work

7f84c33d-7b2f-5e46-9a81-e8d8207a7594

DOI

10.21203/rs.3.rs-7774452/v1