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Article

ISG15 Differentially Modulates Clade Ib and II MPXV Infection in MEF cells

2025-09-26

Abstract excerpt

The unprecedented human-to-human transmission of Clade IIb monkeypox virus (MPXV) during the 2022 outbreak has renewed focus on host determinants of viral fitness. Interferon-stimulated gene 15 (ISG15) encodes a ubiquitin-like protein with broad immunomodulatory functions, yet its role in MPXV infection remains unclear. Using representative strains from recent and historical outbreaks spanning Clades I and II, we...

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Literature Corpus work
85f20c0c-4d34-5694-bdd3-ca05a3d8d5dd
DOI
10.1101/2025.09.26.678780
Open publication

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ISG15 Differentially Modulates Clade Ib and II MPXV Infection in MEF cellsDOI 10.1101/2025.09.26.678780
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