APOBEC3-driven attenuation of the 2022 global outbreak monkeypox virus relative to its clade IIb ancestor.

doi:10.1038/s41467-026-76580-7

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Article

APOBEC3-driven attenuation of the 2022 global outbreak monkeypox virus relative to its clade IIb ancestor.

Nature communications - 11 Aug 2026

Sumner Rebecca P, Eke Lucy, Hernáez Bruno, Hood Alasdair J M, Sancheira Freitas Telma, Ashby Hannah, Ellis Ailish, Petit Marine, Lant Sian, Stokes Isobel, Parija Preetam, Alonso Isabel, Alvarez-de Miranda Francisco J, Unanue Alazne R, Maringer Kevin, Dietrich Isabelle, Charleston Bryan, Smith Geoffrey L, Ulaeto David O, Alcamí Antonio, Maluquer de Motes Carlos

Abstract excerpt

Monkeypox virus (MPXV) is a zoonotic virus endemic to Africa that has recently re-emerged, becoming the first orthopoxvirus with sustained human-to-human transmission since smallpox eradication. The 2022 global epidemic of MPXV was caused by Clade IIb virus (lineage B.1) that derived from the lineage A endemic to West Africa through APOBEC3 microevolution1-3. Here, comparison of lineage B.1 virus with its closest...

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Topics

Animals
Humans
Mice
Monkeypox virus
Mpox, Monkeypox

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mutation

Disease Outbreaks

Cytidine Deaminase

Immunity, Innate

Phylogeny

Virus Replication

Evolution, Molecular

Virulence

Interferon-beta

Source

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Identifiers

PMID: 42711302
DOI: 10.1038/s41467-026-76580-7
PMCID: PMC13554265

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