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Engineered Pseudomonas aeruginosa Ameliorates Rheumatoid Arthritis via CCL4-Dependent Macrophage Repolarization

2025-09-02

Abstract excerpt

<title>Abstract</title> <p> Rheumatoid arthritis (RA) is driven by immune dysregulation, with macrophage polarization playing a central role in disease progression. A critical bottleneck in current rheumatoid arthritis (RA) management is that a subset of patients display inadequate responses to existing anti-inflammatory therapies (e.g., TNF-α inhibitors), leading to persistent inflammation that remains refracto...

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Literature Corpus work
7f49097e-30ac-54eb-a280-7a76e5bb31e8
DOI
10.21203/rs.3.rs-7379444/v1
Open publication

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