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PIKfyve/Fab1 is required for efficient V-ATPase and hydrolase delivery to phagosomes, phagosomal killing, and restriction of <i>Legionella</i> infection

2018-06-09

Abstract excerpt

By engulfing potentially harmful microbes, professional phagocytes are continually at risk from intracellular pathogens. To avoid becoming infected, the host must kill pathogens in the phagosome before they can escape or establish a survival niche. Here, we analyse the role of the phosphoinositide (PI) 5-kinase PIKfyve in phagosome maturation and killing, using the amoeba and model phagocyte Dictyostelium discoid...

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Literature Corpus work
7f20b0f5-e3d1-542d-9396-2cc269f0603d
DOI
10.1101/343301
Open publication

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