Mycobiome Dysbiosis and Genetic Predisposition for Elevated IL-17A Drive Fibrosis in MASLD

Abstract excerpt

<h4>ABSTRACT</h4> Metabolic dysfunction-associated steatotic liver disease (MASLD) is the leading cause of chronic liver disease in Western countries. Progression to metabolic dysfunction-associated steatohepatitis (MASH) occurs when fat accumulation in the liver triggers Th17 activation and other inflammatory processes. In this study, we identify the IL17A rs2275913 minor allele variant as a risk factor for fibro...

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• Clostridium difficile and Clostridium perfringens research
• Dermatology and Skin Diseases
• Diet and metabolism studies
• Gastrointestinal motility and disorders
• Genetic Predisposition to Disease
• Gut microbiota and health
• Lipase
• Liver Disease Diagnosis and Treatment

Identifiers and source

Literature Corpus work

fc38c672-3010-5d6c-942f-40bdcc903085

DOI

10.1101/2024.10.21.24315902