Article

An ultrasensitive method for detecting mutations from short and rare cell-free DNA

2023-03-20

Abstract excerpt

<h4>Background</h4> Cell-free DNA (cfDNA) promises to serve as surrogate biomarkers for non-invasive molecular diagnostics. Disease-specific cfDNA, such as circulating tumor DNA (ctDNA), was short and rare, making the detection performance of the current targeted sequencing methods unsatisfying. <h4>Methods</h4> Through introducing a linear pre-amplification process and optimizing the adapter ligation with customi...

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Literature Corpus work: 7f07be27-7b19-5544-91fc-3ea4e201998c
DOI: 10.1101/2023.03.14.23287139

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