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Article

Automated size selection for short cell-free DNA fragments enriches for circulating tumor DNA and improves error correction during next generation sequencing.

PloS one - 1 Jan 2018

Hellwig Sabine, Nix David A, Gligorich Keith M, O'Shea John M, Thomas Alun, Fuertes Carrie L, Bhetariya Preetida J, Marth Gabor T, Bronner Mary P, Underhill Hunter R

Abstract excerpt

Circulating tumor-derived cell-free DNA (ctDNA) enables non-invasive diagnosis, monitoring, and treatment susceptibility testing in human cancers. However, accurate detection of variant alleles, particularly during untargeted searches, remains a principal obstacle to widespread application of cell-free DNA in clinical oncology. In this study, isolation of short cell-free DNA fragments is shown to enrich for tumor...

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Identifiers

PMID: 30044795
DOI: 10.1371/journal.pone.0197333
PMCID: PMC6059400

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