Article
Prevention of dystrophic pathology in mdx mice by a truncated dystrophin isoform.
Human molecular genetics - 1 Oct 1994
Rafael J A, Sunada Y, Cole N M, Campbell K P, Faulkner J A, Chamberlain J S
Abstract excerpt
The C-terminal domain of dystrophin is alternatively spliced to produce a variety of tissue and developmental stage-specific isoforms. Recent studies suggest that the C-terminal domain binds to the dystrophin-associated glycoprotein complex (DGC) in muscle, but little is known about the functional significance of the alternative splicing or what role individual isoforms may play in specific tissues. The major...
Topics
- Alternative Splicing
- Animals
- Blotting, Western
- Brain
- Dystrophin
- Exons
- Gene Expression
- Immunohistochemistry
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Inbred mdx