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Article

An essential role for RPE-derived soluble VEGF in the maintenance of the choriocapillaris

19 Oct 2009

Abstract excerpt

Clinical and experimental observations indicate a role for VEGF secreted by the retinal pigment epithelium (RPE) in the maintenance of the choriocapillaris (CC). VEGF in mice is produced as three isoforms, VEGF120, VEGF164, and VEGF188, that differ in their ability to bind heparan sulfate proteoglycan. RPE normally produces the more soluble isoforms, VEGF120 and VEGF164, but virtually no VEGF188, reflecting the...

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PMID: 19841260
DOI: 10.1073/pnas.0905010106

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