Article

Dystrophin Dp71 is essential for the development and function of macrophages

2025-04-25

Abstract excerpt

Mutations in the DMD gene, encoding dystrophins, cause progressive muscle degeneration with severe sterile inflammation. While macrophages predominate amongst muscle-infiltrating cells, being central to both damage and regeneration, they were not known to express dystrophin. Yet, we recently demonstrated Dp71 dystrophin expression correlating with tumour infiltrating macrophages. Here we report physiological, dev...

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Literature Corpus work: 8622f3f4-d812-5885-a730-5d679a22674d
DOI: 10.1101/2025.04.24.650386

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